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Bryant, Jack B. VolumeIssue Previous Article Next Article. Richard Click. Junk jack igg 1F. Email alerts Article Activity Alert.

Aster, MD. We recently encountered two patients with severe thrombotic Junk jack igg and persistent thrombocytopenia who responded dramatically to intravenous immunoglobulin G IVIg and performed studies to examine the basis for this effect.

Alperin, MDJack B. Aster, MD Richard H. The constant domain Fc of IgG plays a critical role in mediating this effect. Alperin, MD. Experience with these patients shows that IVIg can be highly effective for treating patients with HIT unresponsive to standard therapies.

Blood 22 : Cite Icon Cite. Bryant, MDBarbara J. Thus there is a need for additional treatment regimens, especially in severely affected patients.

Latest Issue Alert. Content Menu. Mehraboon S. Blood just click for source 22 : Heparin-induced thrombocytopenia HIT is characterized by antibodies abs directed to complexes of PF4 and heparin that are an important cause of morbidity and mortality in heparin-treated patients.

Additional studies are needed to define its role in treating this dangerous condition. Sign In. Google Junk jack igg. Purified IgG Fc junk jack igg are both necessary and sufficient to achieve this effect, while Fab fragments demonstrated no inhibitory activity Fig 1E.

Platelet counts rose dramatically and he was discharged four days later Fig 1A. Fig 1E. Argatroban and then bivalirudin were given, but TP persisted for 17 days Fig 1A. Close Modal.

Bougie, PhD. However strong platelet-activating HIT abs, like those seen in this patient with "delayed HIT" may require only a small amount of PF4 to prime platelets for activation. Irani, MBBChir. View Metrics. This Site. Platelet counts rose sharply and he was discharged one week later. Fig 1C, D and F. Results shown are representative of duplicate determinations. Cited By Google Scholar. Sign In or Create an Account. View large Download slide. Results shown are means and SDs of triplicate determinations. Article Navigation. Jack B. Barbara J. Close Abstract. He was treated with bivalirudin but remained thrombocytopenic with positive HIT test results not shown for 3 weeks Fig 1B. Direct Thrombin inhibitors DTIs and fondaparinux off-label are the mainstays of therapy, but despite their use, thrombosis is common. Bougie, PhD , Daniel W. LP-PEA results shown are the means of duplicate determinations. IVIg doses at 2, 1, 0. Therapeutic plasma exchange TPE was performed on Day 22 with no effect on platelet counts. These results were confirmed using a second HIT ab data not shown. Bryant, MD. Alperin, Mehraboon S. Daniel W.